NMN vs Tretinoin for skin & hair
Short answer: For skin & hair, more users report improvement with NMN — 100% of 14 reports, versus 91% of 35 for Tretinoin.
NMN has 11 meta-analyses and 17 randomized trials on PubMed; Tretinoin has 76 and 265.
Based on 366 reports about NMN and 50 about Tretinoin. Not medical advice.
| NMN Supplement | Tretinoin Medication | |
|---|---|---|
| Users say it helped | 61%helped113 reports · high confidence | 91%helped23 reports · medium confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 11 / 17 | 76 / 265 |
| Mainly used for | ||
| Energy % reporting improvement | 92% (77) | — |
| Skin & hair % reporting improvement | 100% (14) | 91% (35) |
| Sleep % reporting improvement | 65% (20) | — |
| Performance % reporting improvement | 100% (16) | — |
| Mood % reporting improvement | 100% (13) | — |
| Common side effects | insomnia, jitteriness, drowsiness, elevated blood | sunburn, irritation, skin peeling |
| Typical dose reported | 1 g / daily | Not listed |
Overall, NAD⁺ augmentation shows clear biological activity, but clinical effectiveness for anti-aging or wellness outcomes remains inconclusive. Larger, well-designed randomized trials with longer follow-up and prespecified clinically meaningful endpoints are needed, particularly for parenteral approaches.
Ageing Res Rev, 2026 ↗“I've been using NMN for 3 years now, and I had great results with it along with many other supplements. I'm 47 and I look a lot younger and healthier than when I first started NMN.”
These guidelines provide evidence-based recommendations for the management of acne vulgaris.
J Am Acad Dermatol, 2024 ↗“I have gotten good result on the acne front with tretinoin and azelaic acid.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate