NAC vs Tirzepatide for appetite
Short answer: For appetite, more users report improvement with NAC — 91% of 34 reports, versus 84% of 79 for Tirzepatide.
NAC has 387 meta-analyses and 767 randomized trials on PubMed; Tirzepatide has 214 and 132.
Based on 2,058 reports about NAC and 428 about Tirzepatide. Not medical advice.
| NAC Supplement | Tirzepatide Medication | |
|---|---|---|
| Users say it helped | 54%helped947 reports · high confidence | 75%helped287 reports · high confidence |
| Verdict | Mixed | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 387 / 767 | 214 / 132 |
| Mainly used for | ||
| Mood % reporting improvement | 65% (323) | 63% (27) |
| Anxiety % reporting improvement | 90% (301) | — |
| Weight loss % reporting improvement | 80% (5) | 94% (206) |
| Focus % reporting improvement | 81% (170) | 50% (4) |
| Energy % reporting improvement | 73% (91) | 44% (32) |
| Common side effects | anhedonia, stomach issues, depression, emotional blunting | nausea, fatigue, anhedonia, constipation |
| Typical dose reported | 600 mg | Not listed |
Taken together, these preliminary findings suggest that dietetic approaches might be included as part of BD treatment. Also considering the high risk of metabolic disorders in individuals with BD, they should be encouraged to choose healthy dietary lifestyles, including daily intake of fruits, vegetables, seafood and whole grains.
Nutr Neurosci, 2023 ↗“NAC has helped me stay calm and reduce anxiety as well as gives me loads of energy if I am sleep deprived.”
This study shows that new anti-diabetic drugs, particularly GLP1-RA and Tirzepatide, are the most effective in inducing weight loss in patients with type 2 diabetes. Interestingly, exenatide appears to be the only GLP1-RA that induces a mild weight loss.
Pharmacol Res, 2021 ↗“Tirzepatide works so well! Do some research in the r/peptides subreddit and the r/tirzepatide subreddit. It's the most effective thing I've ever seen for appetite suppressant.”
Related comparisons
Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate