Metformin vs Rapamycin for longevity
Short answer: For longevity, users rate them about the same: 100% report improvement with Metformin (11 reports) and 100% with Rapamycin (7 reports).
Metformin has 1,367 meta-analyses and 3,450 randomized trials on PubMed; Rapamycin has 497 and 1,245.
Based on 175 reports about Metformin and 61 about Rapamycin. Not medical advice.
| Metformin Medication | Rapamycin Medication | |
|---|---|---|
| Users say it helped | 29%helped67 reports · medium confidence | 28%helped11 reports · few reports |
| Verdict | Mixed | Mixed |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 1,367 / 3,450 | 497 / 1,245 |
| Mainly used for | ||
| Blood sugar % reporting improvement | 96% (27) | — |
| Longevity % reporting improvement | 100% (11) | 100% (7) |
| Performance % reporting improvement | 0% (15) | — |
| Weight loss % reporting improvement | 90% (10) | — |
| Energy % reporting improvement | 40% (10) | — |
| Common side effects | stomach issues, diarrhea, b12 depletion, nausea | fatigue, slow wound, canker sores, hyperglycemia |
| Typical dose reported | Not listed | Not listed |
The choice of metformin or COCP treatment should be based on symptoms, noting some biochemical benefits from combination treatment targeting both major endocrine disturbances seen in PCOS (hyperinsulinemia and hyperandrogenism).
J Clin Endocrinol Metab, 2024 ↗“Metformin currently has enough data for me personally to feel comfortable not only taking it myself (and my wife), but also recommending it to my patients.”
The majority of the patients reported adverse events limited to grade 1 or 2. On the whole, the data presented herein confirm the findings of previous studies on the relative safety of everolimus, a targeted therapeutic agent, which differs from that of conventional chemotherapy, and highlight the potential adverse events associated with the therapeutic use of everolimus.
Int J Oncol, 2021 ↗“I've noticed a 10% increase in HDL and some fatigue the day after taking more than 6mg.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate