Grape Seed Extract vs Resveratrol for heart & lipids
Short answer: For heart & lipids, more users report improvement with Grape Seed Extract — 100% of 5 reports, versus 75% of 4 for Resveratrol.
Grape Seed Extract has 29 meta-analyses and 60 randomized trials on PubMed; Resveratrol has 282 and 263.
Based on 95 reports about Grape Seed Extract and 277 about Resveratrol. Not medical advice.
| Grape Seed Extract Supplement | Resveratrol Supplement | |
|---|---|---|
| Users say it helped | 75%helped11 reports · few reports | 37%helped75 reports · medium confidence |
| Verdict | Not enough data | Mixed |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 29 / 60 | 282 / 263 |
| Mainly used for | ||
| Longevity % reporting improvement | — | 77% (13) |
| Pain & inflammation % reporting improvement | 67% (3) | 83% (6) |
| Hormones % reporting improvement | 100% (2) | 71% (7) |
| Heart & lipids % reporting improvement | 100% (5) | 75% (4) |
| Focus % reporting improvement | 50% (2) | 67% (6) |
| Common side effects | cold sweats, chills, light headedness | joint pain, aggression, twitching, libido loss |
| Typical dose reported | 200 mg | 0.5 g / daily |
There is moderate-certainty evidence that phlebotonics probably reduce oedema slightly, compared to placebo; moderate-certainty evidence of little or no difference in QoL; and low-certainty evidence that these drugs do not influence ulcer healing. Moderate-certainty evidence suggests that phlebotonics are probably associated with a higher risk of adverse events than placebo. Studies included in this systematic review provided only short-term safety data; therefore, the medium- and long-term safety of phlebotonics could not be estimated. Findings for specific groups of phlebotonics are limited
Cochrane Database Syst Rev, 2020 ↗“anything which helps increase nitric oxide production like grape seed extract should in theory help. I haven’t used Vyvanse in many years but It’s worked for me more recently when using DMAA.”
Topical cosmeceuticals like botanicals, peptides and hydroquinone can effectively treat photodamaged skin.
Skin Res Technol, 2024 ↗“started NMN and resveratrol which I can definitely feel a difference and see the sleep has gotten better since.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate