PlainPill
SupplementFocusAnxietyMood

Vitamin B6 P5P

People mainly take Vitamin B6 P5P for focus, anxiety, mood. Based on 11 first-hand reports and 1 meta-analyses & systematic reviews in the medical literature. Ranked #336 of 1,974 overall.

Compare with…Alternatives for focus
33
User score
Mostly positive
27% positive0% mixed9% negative64% unclear

Of reports that state an outcome, 75% are positive.

Clinical research
BModerate research base
1
meta-analyses
0
RCTs
0
papers

What Vitamin B6 P5P does, according to users

Of the people who reported each effect, the share who said it got better.

Focus100% of 1Anxiety100% of 1Mood100% of 1Energy100% of 1
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

BModerate research base

At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.

Cochrane Database Syst Rev · 2015 · Meta-analysis / systematic review
Pyridoxal 5 phosphate for neuroleptic-induced tardive dyskinesia

Conclusion: Pyridoxal 5 phosphate may have some benefits in reducing the severity of tardive dyskinesia symptoms among individuals with schizophrenia. However, the quality of evidence supporting the effectiveness of pyridoxal 5 phosphate in treating tardive dyskinesia is low, based on few studies, short follow-up periods, small sample sizes and inadequate adherence to standardised reporting guidelines for randomised controlled trials among the included studies.

PubMed 25866243 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

50 mgas reported

Reported side effects

How often each side effect came up across all reports.

neuropathy ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“from all of my favorite vitamins such as Vitamin K, Methylcobalamin or Folate, the P5P form of Vitamin B6”
Source discussion ↗
“I used 50 mg of the P5P version and it's just had this crazy waking up feeling...anxiety which was getting really bad suddenly dropped very low...way more sharp, confident and assertive.”
Source discussion ↗
“Supplementing with Vitamin B6 P5P helped me a lot and might be worth considering.”
Source discussion ↗
“methylfolate, b6 (P5P) and continuing with my methylated b12”
Source discussion ↗
“High dosage Vitamin B6 or P5P can be even better.”
Source discussion ↗
Top discussions (5)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate