PlainPill

Vitamin B12 Methylcobalamin

People mainly take Vitamin B12 Methylcobalamin for focus, memory, mood. Based on 3 first-hand reports and 0 meta-analyses & systematic reviews in the medical literature. Ranked #1619 of 1,974 overall.

6
User score
Mostly negative
0% positive0% mixed33% negative67% unclear

Of reports that state an outcome, 0% are positive.

Clinical research
CLimited research
0
meta-analyses
2
RCTs
15
papers

What Vitamin B12 Methylcobalamin does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

CLimited research

1–4 randomized controlled trials, no meta-analysis yet. The grade measures how much human research exists — read the conclusions below for what it found.

No meta-analyses or systematic reviews published yet — 2 randomized trials found.

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

1000 mcgdaily for 5 days
1 mg1x/week
1 mg1x weekly

Reported side effects

How often each side effect came up across all reports.

brain fog ×1anhedonia ×1cognitive decline ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“I took 1000 mcg B12 for five days...since I have not felt right. I have increased anhedonia, depression, apathy, loss of emotions, cognitive decline”
Source discussion ↗
“Vitamin B12 (Methylcobalamin): 1mg, 1x a week”
Source discussion ↗
Top discussions (3)

Other options for focus

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate