Conclusion: Overall, eszopiclone and lemborexant had a favorable profile, but eszopiclone might cause substantial adverse events and safety data on lemborexant were inconclusive. Doxepin, seltorexant, and zaleplon were well tolerated, but data on efficacy and other important outcomes were scarce and do not allow firm conclusions. Many licensed drugs (including benzodiazepines, daridorexant, suvorexant, and trazodone) can be effective in the acute treatment of insomnia but are associated with poor tolerability, or information about long-term effects is not available. Melatonin, ramelteon, and non-licensed
Does Trazodone help with sleep?
Yes, for most people. 84% of 56 people who reported on Trazodone for sleep say it improved. 14% noticed no change and 2% say it got worse. That is about the typical result for sleep (82% across 71 options).
Sleep: what users report
84%better56 reports · medium confidence
47 better8 no change1 worse
Ranked #25 of 71 for sleep.
What people say about Trazodone and sleep
“I take 1/3 of a serving/dose of Om Sleep and 50mg of trazodone and caps of Tart cherry. The traz gets me to sleep, and the Om keeps me asleep.”
“nothing really beats trazodone so far. Even half of one knocks me out.”
“One that I found particularly useful in this regard, that is also known for not causing dependence is trazodone - 50mg is popular off-label to induce sleep.”
“Well I've had good results with trazodone for sleep. It also doubles as an antidepressant.”
What the research says
AResearch: Strong105 meta-analyses · 165 trials on PubMed
Lancet · 2022
Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysisCNS Drugs · 2024
Effects of Trazodone on Sleep: A Systematic Review and Meta-analysisConclusion: Trazodone extends total sleep time but does not affect perceived sleep duration. It may improve sleep quality and continuity but has minor effects on sleep latency, efficiency, and daytime impairment. Trazodone is associated with adverse effects, necessitating a careful risk-benefit assessment. Limited data restrict generalizability, underscoring the need for more research.
Medicine (Baltimore) · 2025
Chinese herbal medicine for insomnia: A systematic review and network meta-analysisSide effects people mention
drowsiness 10brain fog 4fatigue 2pssd 1emotional blunting 1
Information only — not medical advice. How we count