What are the side effects of Tianeptine?

Users most often report addiction, withdrawal, tolerance, headache, fatigue. Side effects came up 35 times across 322 reports.

User reports can't establish safety. PubMed lists 18 meta-analyses and 42 randomized trials. Talk to a doctor or pharmacist, especially if you take other medication.

Tianeptine side effects

Across 322 first-hand reports, people mentioned a side effect 35 times (about 11 per 100 reports). The most common: addiction, withdrawal, tolerance. User reports show what people notice — they can't tell you whether Tianeptine is safe for you.

Reported side effects

addiction11

withdrawal9

tolerance7

headache2

fatigue2

brain fog2

vivid dreams1

addiction risk1

In their own words

“tianeptine for example. It has done wonders for my anxiety like no other compound. Now I have to choose between remission of anxiety or buying from some rando lab in China because people ODed on it.”

MixedRead the discussion ↗

“Tianeptine works as a powerful anti-depressant for me and many others at small dosages (~12.5mg).”

HelpedRead the discussion ↗

“my least favorite 'noot' of 2015 was tianeptine. That stuff just feels really dirty and unhealthy to me. Even though I was dosing low, I felt very off for a few days after using it.”

Didn't helpRead the discussion ↗

“I was able to successfully quit using low doses of tianeptine. But be careful as that can be an even worse addiction.”

HelpedRead the discussion ↗

“it made my head foggy and made me more anxious. Noticed no improvement in mood.”

MixedRead the discussion ↗

Is Tianeptine safe? What the research covers

AResearch: Strong18 meta-analyses · 42 randomized trials on PubMed

Mol Psychiatry · 2023

Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase: a systematic review and network meta-analysis

Conclusion: Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.

J Child Psychol Psychiatry · 2021

Practitioner Review: Pharmacological treatment of attention-deficit/hyperactivity disorder symptoms in children and youth with autism spectrum disorder: a systematic review and meta-analysis

Conclusion: Direct pooled evidence supports the efficacy and tolerability of methylphenidate or atomoxetine for treatment of ADHD symptoms in children and youth with ASD. The current review highlights the efficacy of standard ADHD pharmacotherapy for treatment of ADHD symptoms in children and youth with ASD. Consideration of the benefits weighed against the limitations of safety/efficacy data and lack of data evaluating long-term continuation is undertaken to help guide clinical decision-making regarding treatment of co-occurring ADHD symptoms in children and youth with ASD.

Front Psychiatry · 2020

Antidepressants in Children and Adolescents: Meta-Review of Efficacy, Tolerability and Suicidality in Acute Treatment

Conclusion: There is a paucity of data on suicidal ideation/behavior, but paroxetine may increase the risk of suicidality in the treatment of AD and venlafaxine for MDD. Findings from this review must be considered in light of potential limitations, such as the lack of comparative information about many antidepressants, the short-term outcomes and the quality of the available evidence.