People mainly take Statins for heart & lipids, blood sugar. Based on 9 first-hand reports and 1,814 meta-analyses & systematic reviews in the medical literature. Ranked #692 of 1,974 overall.
Of reports that state an outcome, 38% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: These results confirm the absence of a neurocognitive risk associated with statin treatment and suggest a potential favourable role of statins. Randomized clinical trials with an ad hoc design are needed to explore this potential neuroprotective effect.
PubMed 34871380 ↗Conclusion: Conclusion: This review further confirms that high-intensity statins reduce LDL by ≥50%, favoring rosuvastatin over atorvastatin. Additional data are needed to confirm the clinical significance on cardiovascular outcomes using real-world studies.
PubMed 36847307 ↗Conclusion: Ezetimibe or PCSK9 inhibitors may reduce non-fatal MI and stroke in adults at very high or high cardiovascular risk who are receiving maximally tolerated statin therapy or are statin-intolerant, but not in those with moderate and low cardiovascular risk.
PubMed 35508321 ↗Conclusion: For primary prevention of cardiovascular disease, the risk of adverse events attributable to statins was low and did not outweigh their efficacy in preventing cardiovascular disease, suggesting that the benefit-to-harm balance of statins is generally favourable. Evidence to support tailoring the type or dosage of statins to account for safety concerns before starting treatment was limited.
PubMed 34261627 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“Satins can result in decreased insulin sensitivity, leading to increased insulin levels which can have a cascading negative health impact”
“statins were associated with a decreased risk of dementia”
“the risk/reward ratio doesn't justify their use in a lot of people. Their side effects are almost certainly understated”
“14 years of statins did there job and calcified the plaque”
“my LDL cholesterol was down to 100, a 50% improvement using 5mg and slightly better eating”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate