PlainPill

Serrapeptase

People mainly take Serrapeptase for pain & inflammation, recovery, libido. Based on 15 first-hand reports and 2 meta-analyses & systematic reviews in the medical literature. Ranked #751 of 1,974 overall.

22
User score
Mostly positive
20% positive0% mixed0% negative80% unclear

Of reports that state an outcome, 100% are positive.

Clinical research
BModerate research base
2
meta-analyses
5
RCTs
32
papers

What Serrapeptase does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

BModerate research base

At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.

Cochrane Database Syst Rev · 2020 · Meta-analysis / systematic review
Treatments for breast engorgement during lactation

Conclusion: Although some interventions may be promising for the treatment of breast engorgement, such as cabbage leaves, cold gel packs, herbal compresses, and massage, the certainty of evidence is low and we cannot draw robust conclusions about their true effects. Future trials should aim to include larger sample sizes, using women - not individual breasts - as units of analysis.

PubMed 32944940 ↗
Cochrane Database Syst Rev · 2016 · Meta-analysis / systematic review
Treatments for breast engorgement during lactation

Conclusion: Although some interventions such as hot/cold packs, Gua-Sha (scraping therapy), acupuncture, cabbage leaves and proteolytic enzymes may be promising for the treatment of breast engorgement during lactation, there is insufficient evidence from published trials on any intervention to justify widespread implementation. More robust research is urgently needed on the treatment of breast engorgement.

PubMed 27351423 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

No doses stated in the reports so far.

Reported side effects

How often each side effect came up across all reports.

No side effects reported so far.

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“The nattokinase and serrapeptase are intended to clean up my fibrolynic system”
Source discussion ↗
“As for supplements, look into : Nattokinase: Serrapeptase: Citrus Bergamot: Turmeric: Cod Liver Oil.”
Source discussion ↗
“Trying pairing it with quercetin, bromelain and serrapeptase. Mind blowing”
Source discussion ↗
“my inflammation is at all time lows”
Source discussion ↗
“Also zinc and NAC, serrapeptase, Quercetin”
Source discussion ↗
Top discussions (5)

Other options for pain & inflammation

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate