S4
People mainly take S4 for performance. Based on 9 first-hand reports. Ranked #908 of 1,974 overall.
19
User score
Mostly positive22% positive0% mixed11% negative67% unclear
Of reports that state an outcome, 67% are positive.
Clinical research
Research pending
High-risk compound. SARMs are not approved as supplements, carry serious and sometimes irreversible risks, are banned in competitive sport and may be restricted where you live. Nothing here is a recommendation to use it.
What S4 does, according to users
Of the people who reported each effect, the share who said it got better.
betterno changeworse
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
Research data for S4 is being compiled.
Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
8 weeksas reported
100 mgas reported
Reported side effects
How often each side effect came up across all reports.
vision side ×1vision issues ×1yellow tinted ×1night blindness ×1yellow tint ×1vision problems ×1
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“I'm am currently running a recomp, all from narrows, with a mix of liquid and caps. I have literally transformed, an absolute recomp to the T.”
“I love lgd. The size and pumps you get is uncomparable...lean gain, muscle hardening and insane vascularity”
“I have access to test I might use as a base if I feel bad to early. Ive ran up to 100mg of s4 with 30mg of mk2866 for 8 weeks before without suppressive symptoms.”
“What about yk11, lgd, rad140, s23, s4, lgd 3303 and multivitamin? Good stack?”
“I will be doing an S4 + LGD4033 cycle next, will be doing the review as time goes with this one.”
Other options for performance
Resistance Training
Lifestyle · 53 reports
100% report better performance
Mostly positive
Retatrutide
Peptide · 298 reports
92% report better performance
Mostly positiveBResearch: Moderate
Tirzepatide
Medication · 219 reports
88% report better performance
Mostly positiveAResearch: Strong
Creatine Monohydrate
Supplement · 139 reports
96% report better performance
Mostly positiveAResearch: Strong
Magnesium Malate
Supplement · 103 reports
100% report better performance
Mostly positiveDResearch: None
Semaglutide
Medication · 137 reports
80% report better performance
Mostly positiveAResearch: Strong
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate