Across 46 first-hand reports, people mentioned a side effect 5 times (about 11 per 100 reports). The most common: other problems, serotonin syndrome, mania. User reports show what people notice — they can't tell you whether Psychedelics is safe for you.
“psychedelics had 'cured' me but I realize now all they had done was send me into manic states”
“LSD is okay, increases mood but gives me other problems”
Conclusion: A review of open-label trials showed robust decreases in depressive symptoms following psilocybin administration. These findings provide preliminary evidence for antidepressant efficacy with psilocybin-assisted psychotherapy, however, further studies are needed to evaluate safety and efficacy and to optimize treatment protocols.
Conclusion: Nearly a third of the articles reported that no participants reported lasting adverse effects. Our analyses suggest that psychedelics reduce negative mood, and have potential efficacy in other mental disorders, such as substance-use disorders and PTSD.
Conclusion: Moderate to high certainty evidence shows that non-inhaled medical cannabis or cannabinoids results in a small to very small improvement in pain relief, physical functioning, and sleep quality among patients with chronic pain, along with several transient adverse side effects, compared with placebo. The accompanying BMJ Rapid Recommendation provides contextualised guidance based on this body of evidence. SYSTEMATIC REVIEW REGISTRATION: https://osf.io/3pwn2.