Conclusion: A review of open-label trials showed robust decreases in depressive symptoms following psilocybin administration. These findings provide preliminary evidence for antidepressant efficacy with psilocybin-assisted psychotherapy, however, further studies are needed to evaluate safety and efficacy and to optimize treatment protocols.
Does Psychedelics help with mood?
Possibly — but there are few reports. 82% of 11 people who reported on Psychedelics for mood say it improved. 9% noticed no change and 9% say it got worse.
What people say about Psychedelics and mood
“Have you tried psychedelics? They helped me have so much compassion for myself.”
“psychedelics had 'cured' me but I realize now all they had done was send me into manic states”
“I started using psychedelics , mostly microdosing. I feel those have been tremendously beneficial to me, especially DMT.”
“every different psychedelic I have tried has always worked great for it too”
What the research says
Conclusion: Nearly a third of the articles reported that no participants reported lasting adverse effects. Our analyses suggest that psychedelics reduce negative mood, and have potential efficacy in other mental disorders, such as substance-use disorders and PTSD.
Conclusion: Treatment effects of psilocybin were significantly larger among patients with secondary depression, when self-report scales were used to measure symptoms of depression, and when participants had previously used psychedelics. Further research is thus required to delineate the influence of expectancy effects, moderating factors, and treatment delivery on the efficacy of psilocybin as an antidepressant.
Side effects people mention
Based on few reports — treat as anecdotal. Information only — not medical advice. How we count