People mainly take Nicotinic Acid for energy, anxiety, mood. Based on 13 first-hand reports and 32 meta-analyses & systematic reviews in the medical literature. Ranked #455 of 1,974 overall.
Of reports that state an outcome, 62% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: ezetimibe, fibrates, niacin (nicotinic acid), reduced- or modified-fat diet, resins, and statins.
PubMed 21418693 ↗Conclusion: Although the studies were conducted before statin therapy become standard care, and mostly in patients in secondary prevention, with various dosages of nicotinic acid 1-3g/day, this meta-analysis found positive effects of niacin alone or in combination on all cardiovascular events and on atherosclerosis evolution.
PubMed 20079494 ↗Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: anion exchange resins, combined treatments (for lipid modification), ezetimibe, fibrates, fish oil (for lipid modification), intensive multiple intervention treatment programmes (for lipid modification), nicotinic acid (for lipid modification), and statins.
PubMed 19450295 ↗Conclusion: Potential risks in raising NAD+ levels in various clinical disorders using NAD+ precursors include the accumulation of putative toxic metabolites, tumorigenesis and promotion of cellular senescence. Therefore, NAD+ metabolism represents a promising target and further studies are needed to recapitulate the preclinical benefits in human clinical trials.
PubMed 31917996 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“take vitamin D and nicotinic acid supplements. Nicotinic acid will help convert tryptophan to serotonin much more effectively”
“Some of the lower cost ones I really value include: Nicotinic Acid (more so than any other NMN precursor)”
“Nicotinic Acid for NAD production and peripheral blood circulation boost”
“I developed a severe form of peripheral neuropathy - small fiber. I've been through hell.”
“taking histamine-increasing supplements like Zinc, L-Histidine, Manganese, Nicotinic Acid and Vitamin C.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate