People mainly take Nadh for energy. Based on 18 first-hand reports and 27 meta-analyses & systematic reviews in the medical literature. Ranked #792 of 1,974 overall.
Of reports that state an outcome, 50% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: NADH supplementation is safe and has a low incidence of side effects. Future investigations are needed to evidence the clinical benefits regarding specific diseases and doses administered.
PubMed 37971292 ↗Conclusion: We also provide an excursus on the relative contribution of cardiomyocytes, fibroblasts, endothelial and smooth muscle cells to the pathophysiology of heart failure in diabetes. After having described the preclinical tools currently available to dissect the mechanisms of this complex disease, we conclude with a section on the most recent updates of the literature on clinical management.
PubMed 34627874 ↗Conclusion: Conclusions: Though some DSs showed potential in reducing fatigue in ME/CFS, methodological limitations and inconsistent results hinder definitive conclusions. Future research should improve diagnostic criteria and include more diverse populations.
PubMed 39940333 ↗Conclusion: The pooled results showed that there was a significant association between mtDNA T4216C variation and MS (OR = 1.38, 95 % CI = 1.13-1.67, P = 0.001). The present systematic review and meta-analysis suggest that mtDNA T4216C variation is a contributory factor in susceptibility to MS.
PubMed 27457485 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“NADH (gives me energy)”
“tried NADH? different from all the NAD+ stuff everyone pushes here, actually worked for my post-covid fog”
“Have tried everything from NADH, all the activated B's, b12/folate, Tianeptine, Noopept, D-Aspartic Acid, Aniracetam, Phenibut, Pregnenolone”
“supplementing NADH (cofactor of BH4 production) just gives energy thats about it”
“Now I've started with NADH for a couple of days.”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate