People mainly take NAD+ for energy, focus, longevity. Based on 125 first-hand reports and 109 meta-analyses & systematic reviews in the medical literature. Ranked #173 of 1,974 overall.
Of reports that state an outcome, 60% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: NADH supplementation is safe and has a low incidence of side effects. Future investigations are needed to evidence the clinical benefits regarding specific diseases and doses administered.
PubMed 37971292 ↗Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: antidepressants, cognitive behavioural therapy (CBT), corticosteroids, dietary supplements, evening primrose oil, galantamine, graded exercise therapy, homeopathy, immunotherapy, intramuscular magnesium, oral nicotinamide adenine dinucleotide, and prolonged rest.
PubMed 19445810 ↗Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: antidepressants, cognitive behavioural therapy (CBT), corticosteroids, dietary supplements, evening primrose oil, galantamine, graded exercise therapy, homeopathy, immunotherapy, intramuscular magnesium, oral nicotinamide adenine dinucleotide, and prolonged rest.
PubMed 21615974 ↗Conclusion: The random-effects meta-analyses indicated no significant benefit of NMN on fasting glucose, fasting insulin, glycated hemoglobin, homeostatic model assessment for insulin resistance and lipid profile. Based on the small number of RCTs involving mainly relatively healthy adults, short-term supplementation of NMN of 250-2000 mg/d did not show significantly positive impacts on glucose control and lipid profile.
PubMed 39531138 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“The NAD+ I have used on occasion and the pterostilbene also on occasion. Never noticed side effects with those.”
“I actually inject myself with NAD+ on a weekly basis and have been doing so for the past 6 months. I no longer struggle with brain fog or general fatigue.”
“I feel more energy I think but I also think only the NAD is doing anything”
“It seems like NAD gets you back to youthful levels of health, but isn’t going to supercharge anyone who is still there.”
“I'd add clomid, peptides and nad”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate