PlainPill

Multivitamins

People mainly take Multivitamins for energy. Based on 12 first-hand reports and 67 meta-analyses & systematic reviews in the medical literature. Ranked #1428 of 1,974 overall.

11
User score
Mostly negative
0% positive8% mixed42% negative50% unclear

Of reports that state an outcome, 0% are positive.

Clinical research
AStrong research base
67
meta-analyses
203
RCTs
2,034
papers

What Multivitamins does, according to users

Of the people who reported each effect, the share who said it got better.

betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

BMJ Clin Evid · 2011 · Meta-analysis / systematic review
Eczema

Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: breastfeeding, controlling house dust mites, corticosteroids, dietary exclusion of eggs or cow's milk, elementary diets, emollients, essential fatty oils, few-foods diet, multivitamins, pimecrolimus, probiotics, pyridoxine, reducing maternal dietary allergens, tacrolimus, vitamin E, and zinc supplements.

PubMed 21609512 ↗
J Am Coll Cardiol · 2021 · Meta-analysis / systematic review
Supplemental Vitamins and Minerals for Cardiovascular Disease Prevention and Treatment: JACC Focus Seminar

Conclusion: No effect was seen for the commonly used multivitamins, vitamin D, calcium, and vitamin C, and an increased risk was seen with niacin (with statin) for all-cause mortality. Conclusive evidence for the benefit of supplements across different dietary backgrounds, when the nutrient is sufficient, has not been demonstrated.

PubMed 33509399 ↗
Cochrane Database Syst Rev · 2023 · Meta-analysis / systematic review
Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration

Conclusion: Moderate-certainty evidence suggests that antioxidant vitamin and mineral supplementation (AREDS: vitamin C, E, beta-carotene, and zinc) probably slows down progression to late AMD. People with intermediate AMD have a higher chance of benefiting from antioxidant supplements because their risk of progression is higher than people with early AMD. Although low-certainty evidence suggested little effect with lutein/zeaxanthin alone compared with placebo, exploratory subgroup analyses from one large American study support the view that lutein/zeaxanthin may be a suitable replacement for the beta-ca

PubMed 37702300 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

dailyas reported
before and day after drinkingas reported
daily in afternoonas reported

Reported side effects

How often each side effect came up across all reports.

excess folic ×1nutrient antagonism ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

Other options for energy

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate