Conclusion: PrEP is safe and effective in MSM, serodiscordant couples and PWIDs. Additional research is needed prior to recommending PrEP in heterosexuals. No RCTs reported effectiveness or safety data for other high-risk groups, such as transgender women and sex workers.
Msm side effects
Across 157 first-hand reports, people mentioned a side effect 9 times (about 6 per 100 reports). The most common: vivid dreams, methylation shift, digestion issues. User reports show what people notice — they can't tell you whether Msm is safe for you.
Reported side effects
vivid dreams2
methylation shift1
digestion issues1
insomnia1
anxiety1
brain fog1
fatigue1
liver discomfort1
In their own words
“It's so good for my skin, nails and hair, but the side effects terrified me.”
“I take it everyday for joint pain. If I miss it for a couple of days I notice the pain starting to return. For me it works great.”
“I've noticed improved sleep and liver function, increased hair growth, more mental and physical energy, and better skin quality.”
“I've been on about 30g a day - 4g an hour, for the past week and the energy and wellbeing is insane!”
“I have also tried glucosamine and MSM for 6-month periods, and they never seemed to make any difference.”
“I have tried a LOT of supplements (glucosamin, chondroitin, MSM, boron, boswellia, serrapeptase, turmeric, fish oil, D3, K2, celadrin...) and nothing helps”
Is Msm safe? What the research covers
AResearch: Strong506 meta-analyses · 423 randomized trials on PubMed
BMJ Open · 2022
Oral pre-exposure prophylaxis (PrEP) to prevent HIV: a systematic review and meta-analysis of clinical effectiveness, safety, adherence and risk compensation in all populationsInt J Cancer · 2022
A systematic review and meta-analysis of cytology and HPV-related biomarkers for anal cancer screening among different risk groupsConclusion: Limited data on other biomarkers (HPV E6/E7 mRNA and p16/Ki-67 dual stain), suggested higher specificity, but lower sensitivity compared with anal cytology and HPV. Our findings provide important evidence for the development of clinical guidelines using anal cytology and HPV testing for anal cancer screening.