Often, yes. 79% of 24 people who reported on Lamotrigine for mood say it improved. 13% noticed no change and 8% say it got worse. That is below the typical result for mood (84% across 108 options).
Ranked #72 of 108 for mood.
“It helped me stay on Lamotrigine, which is the only med that works for my depression.”
“I’ve since trialled Pregabalin and currently been on Lamotrigine for 7 weeks and zero improvement.”
“I was on Seroquel briefly, but found lamotrigine to be much more effective with less side effects.”
“Failed Lamictal Trial, I actually tried Lamictal (25mg) for just one day, but it immediately blunted some of the positive stimulant effect, almost got in a car accident, and made me feel so flat that I panicked and stopped.”
Conclusion: There is substantial evidence for the efficacy of lamotrigine in BD, specifically as add-on treatment during acute depressive episodes and as maintenance treatment for preventing relapse and recurrence.
Conclusion: This is, to our knowledge, the largest network meta-analysis of pharmacotherapy for bipolar depression to date. Olanzapine plus fluoxetine, quetiapine, olanzapine, lurasidone, lumateperone, cariprazine, and lamotrigine were found to be more efficacious than placebo in adults with acute bipolar depression, with good confidence in the evidence, and to differ in their side-effect profiles. These findings can inform evidence-based care and the development of treatment guidelines internationally.
Conclusion: Lurasidone+LIT/VAL and quetiapine+LIT/VAL outperformed placebo+LIT/VAL for all-cause discontinuation. Treatment efficacy, tolerability, and safety profiles differed among treatments.
Information only — not medical advice. How we count