Across 37 first-hand reports, people mentioned a side effect 12 times (about 32 per 100 reports). The most common: joint pain, dry skin, liver damage. User reports show what people notice — they can't tell you whether Isotretinoin is safe for you.
“I have been on low dose accutane for the last month and I can feel my skin is less oily and has been nice and clear. Only slightly chapped lips, no other side effects.”
“I was on axcutane i that shit was the worst thing i every tryed. I sleep all they day and was so exosted i could bearly did a workout. And my bones would hurt.”
“it (most likely) has given me a bunch of side effects like joint/tendon problems and hair loss, but on the other side my cystic acne was severely affecting me mentally”
“Accutane fucked my life... I took accutane for 5 months and my skin has been super clear ever since.”
“about 15 years ago I was put on Accutane (for acne) and was on pain pills for 2 years. After I got done with those, these problems started happening.”
“I took two 6 month rounds of accutane, haven’t seen another zit on my face since, but bacne came back severely after each time.”
Conclusion: Daily doses between 0.1 and 0.3 mg/kg can be recommended for more than 6 months due to the occurrence of fewer side effects and more economical concerns. For greater effectiveness, it could be combined with other medications.
Conclusion: In this systematic review we present information relating to the effectiveness and safety of the following interventions: topical treatments (adapalene, azelaic acid, benzoyl peroxide, clindamycin, erythromycin (alone or plus zinc), isotretinoin, tetracycline, tretinoin), and oral treatments (doxycycline, isotretinoin, lymecycline, minocycline, oxytetracycline, tetracycline).