Int J Dermatol · 2025
Glutathione as a skin-lightening agent and in melasma: a systematic reviewConclusion: IV glutathione is contraindicated due to lack of efficacy and side effects. It may work more as an antioxidant in melasma.
Glutathione side effects
Across 156 first-hand reports, people mentioned a side effect 9 times (about 6 per 100 reports). The most common: injection site, insomnia, stomach issues. User reports show what people notice — they can't tell you whether Glutathione is safe for you.
Reported side effects
injection site2
insomnia1
stomach issues1
weakness1
panic1
high blood1
scar tissue1
injection pain1
In their own words
“maybe the quality is great but I didn't get any feeling from his glutathione, for example.”
“I take liposomal glutathione from Formline somewhat regularly - really helps when I'm feeling sick or fatigued”
“I've paid the unholy cost for liposomal glutathione as well but can't say i've ever noticed an effect from it”
“i’ve found really good results pinning 0.5mL (100mg) a few times weekly. enjoy the pip 😉”
Is Glutathione safe? What the research covers
AResearch: Strong967 meta-analyses · 1,685 randomized trials on PubMed