PlainPill

Does Diphenhydramine help with sleep?

Yes, for most people. 85% of 59 people who reported on Diphenhydramine for sleep say it improved. 5% noticed no change and 10% say it got worse. That is about the typical result for sleep (82% across 71 options).

Sleep: what users report
85%better59 reports · medium confidence
50 better3 no change6 worse

Ranked #21 of 71 for sleep.

What people say about Diphenhydramine and sleep

“Benadryl works the best when there is nothing else I can do and I take it a lot but probably not the best way to get sleep.”
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“i can't sleep at all when i take that stuff. Makes me paranoid.”
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“I hate to rely on it, but our old friend Benadryl works pretty well.”
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“Had insomnia and tested out a Benadryl and trazadone. Felt weird and nervous but it let me sleep at least.”
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What the research says

AResearch: Strong57 meta-analyses · 298 trials on PubMed
Hum Psychopharmacol · 2023
Efficacy and safety of hydroxyzine for sleep in adults: Systematic review

Conclusion: The studies in this review suggest hydroxyzine could be considered as a short-term treatment option for adults with insomnia for whom previous therapy was ineffective, not tolerated, or contraindicated. Additional long-term studies with an active comparator are needed to further establish its role in insomnia treatment.

Side effects people mention

drowsiness 21brain fog 14anticholinergic 4confusion 3tolerance 3

What else is Diphenhydramine used for?

Information only — not medical advice. How we count

Does Diphenhydramine help with sleep? 85% of 59 users say yes — PlainPill