Across 157 first-hand reports, people mentioned a side effect 6 times (about 4 per 100 reports). The most common: erectile dysfunction, tooth erosion, tooth enamel. User reports show what people notice — they can't tell you whether Citrulline is safe for you.
“I tried so many things – L-Arginine, Citrulline, Zinc, Omega-3s, training, clean diet. Some things helped a bit, but nothing really fixed it.”
“I tried Iodine,SSRI,Selenium,Rhodiola Rosea,Tongkat Ali,Citrulline,Carnivore Diet,Maca but nothing worked”
“I started taking it and then had erectile dysfunction. It was useful with a web search to confirm that some other men had experience the same.”
“you might pick up some citruline for that circulation as well but mix it into a beverage as it can eat the enamel off your teeth. I don't need it but it can make me mountain bike for 10 hours no prob.”
Conclusion: Supplementation of some but not all micronutrients may benefit cardiometabolic health. This study highlights the importance of micronutrient diversity and the balance of benefits and risks to promote and maintain cardiovascular health in diverse populations. (Antioxidant Supplementation in the Prevention and Treatment of Cardiovascular Diseases; CRD42022315165).