Conclusion: Compared to placebo, venlafaxine was associated with a lower incidence of dizziness, while desvenlafaxine, sertraline, and vortioxetine were associated with a higher incidence of nausea/vomiting. In conclusion, desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.
Citalopram side effects
Across 42 first-hand reports, people mentioned a side effect 22 times (about 52 per 100 reports). The most common: sexual dysfunction, anhedonia, emotional numbness. User reports show what people notice — they can't tell you whether Citalopram is safe for you.
Reported side effects
What got worse for some people
In their own words
“After 2 weeks I felt numb and my whole sex drive was gone.”
“I quit taking it after about 25 days because it made me totally numb and lose all pleasure and function, including sexual.”
“I only took them for those 25 days and quit because it made me feel 100% numb with zero emotions or pleasure. Over 6 years later I am still stuck this way.”
“I was on it for a week and immediately had insane generalized anxiety/fear/panic a couple days in.”
“I have given very few of them fair trials, as I can't deal with the side effects for that long.”
“it made me totally numb and lose all pleasure and function, including sexual. I couldn't feel emotions or even an orgasm at all.”
Is Citalopram safe? What the research covers
Conclusion: Escitalopram was superior to other ADs for the acute phase treatment of MDD in terms of efficacy, acceptability and tolerability. However, no significant difference was found between escitalopram and other ADs in early response or follow-up response to treatment of MDD.
Conclusion: For the most commonly used second-generation antidepressants, the lower range of the licensed dose achieves the optimal balance between efficacy, tolerability, and acceptability in the acute treatment of major depression.