Milk Thistle vs Tudca for hormones
Short answer: For hormones, more users report improvement with Tudca — 100% of 3 reports, versus 83% of 6 for Milk Thistle.
Milk Thistle has 26 meta-analyses and 39 randomized trials on PubMed; Tudca has 4 and 14.
Based on 246 reports about Milk Thistle and 158 about Tudca. Not medical advice.
| Milk Thistle Supplement | Tudca Supplement | |
|---|---|---|
| Users say it helped | 60%helped49 reports · medium confidence | 80%helped32 reports · medium confidence |
| Verdict | Mostly positive | Mostly positive |
| Research | AResearch: Strong | AResearch: Strong |
| Meta-analyses / RCTs | 26 / 39 | 4 / 14 |
| Mainly used for | ||
| Digestion % reporting improvement | 50% (2) | 86% (7) |
| Hormones % reporting improvement | 83% (6) | 100% (3) |
| Pain & inflammation % reporting improvement | 80% (5) | 100% (3) |
| Common side effects | stomach issues, diarrhea, serotonin syndrome, hypothyroidism | liver stress, bad taste, h2s overgrowth |
| Typical dose reported | 500 mg / daily | 250 mg / morning |
Silymarin can regulate energy metabolism, attenuate liver damage, and improve liver histology in NAFLD patients. However, the effects of silymarin will need to be confirmed by further research.
Ann Hepatol, 2024 ↗“Adrafinil and milk thistle is my current best solution...Milk thistle helps for the hepatoxicity (as you know)”
This systematic review demonstrated that TUDCA has neuroprotective effect on in vivo and in vitro models of retinal disorders, reinforcing the currently available evidence that TUDCA could be a promising therapeutic agent in retinal diseases treatment. However, well designed clinical trials are necessary to appraise the efficacy of TUDCA in clinical setting.
Curr Neuropharmacol, 2024 ↗“While I do take TUDCA primarily for liver health, anecdotally I've noticed... Slight increase in sense of overall wellbeing.”
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Percentages come from first-hand user reports and are not clinical outcomes. Talk to a doctor before starting, stopping or combining anything. How we rate