People mainly take Vitamin D2 for anxiety, mood, energy. Based on 9 first-hand reports and 32 meta-analyses & systematic reviews in the medical literature. Ranked #964 of 1,974 overall.
Of reports that state an outcome, 14% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Vitamin D supplementation may have beneficial effects on HT patients by modulating immune responses and improving thyroid function.
PubMed 38206745 ↗Conclusion: This meta-analysis indicates that vitamin D3 is more efficacious at raising serum 25(OH)D concentrations than is vitamin D2, and thus vitamin D3) could potentially become the preferred choice for supplementation. However, additional research is required to examine the metabolic pathways involved in oral and intramuscular administration of vitamin D and the effects across age, sex, and ethnicity, which this review was unable to verify.
PubMed 22552031 ↗Conclusion: Specifically, improvements in strength ranged from 1.37 to 18.75%. Additional studies are needed to confirm these associations.
PubMed 27379960 ↗Conclusion: Vitamin D3 leads to a greater increase of 25(OH)D than vitamin D2, even if limited to daily dose studies, but vitamin D2 and vitamin D3 had similar positive impacts on their corresponding 25(OH)D hydroxylated forms. Next to baseline 25(OH)D concentration, BMI should be considered when comparing the effect of daily vitamin D2 and vitamin D3 supplementation on total 25(OH)D concentration. This study was registered in PROSPERO as CRD42021272674.
PubMed 37865222 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“A daily dose of 4000 IU of vitamin D3 for two weeks was observed to be 1.7 times more effective in raising 25[OH]D levels than 4000 IU of vitamin D2.”
“D2 raises my levels but without any side effects. If you feel funky with D3, go back to D2.”
“doc prescribed 50,000 units weekly of D2 taken orally for 3 months”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate