PlainPill
SupplementMoodFocusSleep

Uridine Monophosphate

People mainly take Uridine Monophosphate for mood, focus, sleep. Based on 45 first-hand reports and 7 meta-analyses & systematic reviews in the medical literature. Ranked #562 of 1,974 overall.

Compare with…Alternatives for mood
25
User score
Mixed
13% positive11% mixed2% negative73% unclear

Of reports that state an outcome, 50% are positive.

Clinical research
BModerate research base
7
meta-analyses
7
RCTs
508
papers

What Uridine Monophosphate does, according to users

Of the people who reported each effect, the share who said it got better.

Mood100% of 4Focus100% of 3Sleep67% of 3Energy67% of 3
3 more with fewer than 3 reports
Memory100% of 1Anxiety100% of 1Blood sugar100% of 1
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

BModerate research base

At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.

Clin Liver Dis · 2011 · Meta-analysis / systematic review
The HCV NS5B nucleoside and non-nucleoside inhibitors

Conclusion: Through a systematic review of the published literature, we describe their structure, mechanism of action, issues with resistance, and clinical effectiveness shown in the latest clinical trials. Direct-acting antiviral combination trials that have already shown some early promising results even in the setting of interferon-sparing antiviral regimens are discussed.

PubMed 21867940 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

300 mg1-2x daily
60 mg2x daily
250 mgdaily
350 mgas reported
100-175 mgdaily
150 mgas reported

Reported side effects

How often each side effect came up across all reports.

mania ×2anomic aphasia ×1fatigue ×1tremors ×1insomnia ×1psychosis ×1drowsiness ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“I would try uridine monophosphate and alpha gpc which has a beneficial effect on dopamine receptors by building them up.”
Source discussion ↗
“Uridine Monophosphate (UMP)”
Source discussion ↗
“I've completely cut caffeine from my diet. The 'energy' and alertness this stuff gives is way better.”
Source discussion ↗
“The stack is beginning to make its way through the nootropics community on the web, and I wanted to take this opportunity to answer questions about the stack”
Source discussion ↗
“Uridine monophosphate helped me with this”
Source discussion ↗
Top discussions (5)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate