Trimethylglycine
People mainly take Trimethylglycine for mood. Based on 11 first-hand reports and 0 meta-analyses & systematic reviews in the medical literature. Ranked #962 of 1,974 overall.
Of reports that state an outcome, 33% are positive.
What Trimethylglycine does, according to users
Of the people who reported each effect, the share who said it got better.
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
1–4 randomized controlled trials, no meta-analysis yet. The grade measures how much human research exists — read the conclusions below for what it found.
Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“I believe TMG is a derivative of Choline and not a source of it.”
“You can test this by taking trimethylglycine (TMG). If that gives you the same symptoms the methyl groups is without a doubt the cause.”
“I'll be taking trimethylglycine (TMG) every other day as an alternative methyl donor”
“You might want to look into trimethylglycine as well.”
“1-3g TriMethylGlycine.”
Other options for mood
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate