People mainly take Riboflavin for pain & inflammation. Based on 9 first-hand reports and 114 meta-analyses & systematic reviews in the medical literature. Ranked #907 of 1,974 overall.
Of reports that state an outcome, 100% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: This guideline should enable addressing suboptimal and deficient status of a bundle of MNs in at-risk diseases. In particular, it offers practical advice on MN provision and monitoring during nutritional support.
PubMed 35365361 ↗Conclusion: A pooled analysis of available randomized controlled clinical trials demonstrated that Vitamin B2 400 mg/day for three months supplementation had significant effect on days, duration, frequency, and pain score of migraine attacks.
PubMed 33779525 ↗Conclusion: The use of certain dietary supplements has resulted in a significant decrease in migraine prophylaxis. Further clinical trials of high quality appear to be beneficial.
PubMed 39404918 ↗Conclusion: Children with ASD are statistically significantly shorter than TDC, which can be explained by the lower protein intake and fat- and water-soluble vitamin status and intake. These findings warrant further longitudinal population-based studies.
PubMed 40708203 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“Low riboflavin.”
“Riboflavin is used in B6 utilization, so it's possible that by supplementing Riboflavin you can get the B6 process running faster”
“After my mTBI magnesium and riboflavin were amazing at alleviating PCT headaches”
“I can certainly tell the difference since I added choline, creatine, glycine, methylfolate, riboflavin and a non-cyanocobalamin B-12 to my daily routine.”
“Riboflavin CoQ10 Magnesium Bioflavonoids Acetyl-L-carnitine Taurine choline (3 forms)”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate