People mainly take Pomegranate Extract for heart & lipids. Based on 6 first-hand reports and 15 meta-analyses & systematic reviews in the medical literature. Ranked #1471 of 1,974 overall.
Of reports that state an outcome, 0% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc. However, more RCTs are needed to verify or modify the efficacy and safety of dietary polyphenols.
PubMed 37033930 ↗Conclusion: The systematic review is registered in PROSPERO under ID CRD420251010982. https://www.crd.york.ac.uk/PROSPERO/view/CRD420251010982.
PubMed 41030267 ↗Conclusion: Since this study has evaluated mostly Eastern countries' studies it could be concluded that pomegranate supplements are effective in modifying oxidative stress in Eastern countries. The evidence to support this study is low, therefore, needs the future studies to confirm the results.
PubMed 35405162 ↗Conclusion: This evidence-based review highlighted the potential of pomegranate extract being used for treating bone loss in osteoporosis, osteoarthritis and rheumatoid arthritis. Further studies are required to identify the active ingredients and molecular mechanisms before controlled human observational studies are conducted to provide stronger evidence.
PubMed 24200293 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“Pomegranate extract - to hopefully be converted into Urolithin A”
“Pomegranate Extract 1200mg - LOW /similar to pycnogenol, pomegranates have been showen to increase NO, but testing multiple times showed nothing”
“Add in pomegranate extract if you want to quickly lower and balance your cholesterol.”
“Life Extension blueberry extract plus pomegranate extract is good and well priced.”
“Here is a list of what I tried that either had no effect or little effect”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate