PlainPill

Pistachios

Based on 3 first-hand reports and 22 meta-analyses & systematic reviews in the medical literature. Ranked #1594 of 1,974 overall.

6
User score
Not enough data
0% positive0% mixed0% negative100% unclear

Of reports that state an outcome, 0% are positive.

Clinical research
AStrong research base
22
meta-analyses
35
RCTs
498
papers

What Pistachios does, according to users

Of the people who reported each effect, the share who said it got better.

No specific effects reported yet.
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

Crit Rev Food Sci Nutr · 2022 · Meta-analysis / systematic review
Functional foods modulating inflammation and metabolism in chronic diseases: a systematic review

Conclusion: Foods identified to regulate inflammation included cranberries, grapes, pomegranate, strawberries, wheat, whole grain products, low fat dairy products, yogurt, green tea, cardamom, turmeric, soy foods, almonds, chia seeds, flaxseed, pistachios, algae oil, flaxseed oil and grape seed oil. Clinical trials that focus on a dietary pattern rich in functional foods are necessary to explore if the additive effect of these foods lead to more clinically relevant outcomes.

PubMed 33506690 ↗
Complement Ther Med · 2020 · Meta-analysis / systematic review
Pistachios and cardiometabolic risk factors: A systematic review and meta-analysis of randomized controlled clinical trials

Conclusion: This systematic review and meta-analysis demonstrates that pistachios consumption can elicit a beneficial effect on some cardiometabolic risk factors. All previous clinical studies are well designed but some points have still remained unclear including the effects of different pistachios dosages on cardio metabolic risk factors and efficacy of pistachios consumption in preventing endothelial dysfunction. Further examination is required to determine the effect of pistachios consumption on further endothelial function risk factors.

PubMed 32951758 ↗
Br J Nutr · 2023 · Meta-analysis / systematic review
Effects of pistachios on glycaemic control: a systematic review and meta-analysis of randomised controlled trials

Conclusion: Pistachio consumption may improve glucoregulatory status in individuals at risk for CVD, as evidenced by reduced FBS and insulin concentrations. However, due to the limited availability of studies with diabetic cases and relatively small sample sizes of available studies, well-designed trials with adequate sample sizes aimed at diabetic populations are recommended.

PubMed 35795961 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

handfuldaily

Reported side effects

How often each side effect came up across all reports.

No side effects reported so far.

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“pistachios which are high in melatonin. Eat a handful of each with dinner”
Source discussion ↗
“Pistachios are the best source of melatonin.”
Source discussion ↗
“pistachios feed your gut bacteria necessary for breaking down tmao, eat a handful of them every day for awhile and you'll be fine. trust me bro.”
Source discussion ↗
Top discussions (3)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate