PlainPill
SupplementMoodAnxietyEnergy

P5P

People mainly take P5P for mood, anxiety, energy. Based on 38 first-hand reports and 1 meta-analyses & systematic reviews in the medical literature. Ranked #954 of 1,974 overall.

Compare with…Alternatives for mood
15
User score
Mostly positive
24% positive3% mixed11% negative63% unclear

Of reports that state an outcome, 63% are positive.

Clinical research
BModerate research base
1
meta-analyses
3
RCTs
64
papers

What P5P does, according to users

Of the people who reported each effect, the share who said it got better.

Mood50% of 4Anxiety100% of 3
6 more with fewer than 3 reports
Energy100% of 2Sleep100% of 2Libido100% of 1Weight loss100% of 1Hormones100% of 1Performance100% of 1
betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

BModerate research base

At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.

Cochrane Database Syst Rev · 2015 · Meta-analysis / systematic review
Pyridoxal 5 phosphate for neuroleptic-induced tardive dyskinesia

Conclusion: Pyridoxal 5 phosphate may have some benefits in reducing the severity of tardive dyskinesia symptoms among individuals with schizophrenia. However, the quality of evidence supporting the effectiveness of pyridoxal 5 phosphate in treating tardive dyskinesia is low, based on few studies, short follow-up periods, small sample sizes and inadequate adherence to standardised reporting guidelines for randomised controlled trials among the included studies.

PubMed 25866243 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

2 weeksas reported
25 mg - 75 mgdaily
50 mgas reported
50mgas reported

Reported side effects

How often each side effect came up across all reports.

b6 toxicity ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“I personally use p5p, tyrosine, vitamin c, and caffeine together. The first 3 specifically help the body create and utilize dopamine and norepinephrine, thus making my mood and motivation higher”
Source discussion ↗
“p5p”
Source discussion ↗
“P5P is more effective and just as cheap/available, could aslo stack both.”
Source discussion ↗
“None of these have made any difference to my mood.”
Source discussion ↗
“P5P”
Source discussion ↗
Top discussions (5)

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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate