PlainPill

Nitrous Oxide

People mainly take Nitrous Oxide for anxiety, mood. Based on 2 first-hand reports. Ranked #1252 of 1,974 overall.

14
User score
Mostly negative
50% positive0% mixed50% negative0% unclear

Of reports that state an outcome, 50% are positive.

Clinical research
Research pending

What Nitrous Oxide does, according to users

Of the people who reported each effect, the share who said it got better.

betterno changeworse

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

Research data for Nitrous Oxide is being compiled.

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

50% nitrous oxide with 50% oxygensingle 1-hour inhalation

Reported side effects

How often each side effect came up across all reports.

brain damage ×2nerve damage ×1b12 destruction ×1anemia ×1demyelination ×1b12 depletion ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“A month later (end of January 2020), the patient reported a PHQ-9 score of 0, indicating full remission, and again in mid-February he reported a PHQ-9 score of 0.”
Source discussion ↗
“whippets are a solid choice, prevents your body from absorbing b12 and kills brain cells like immediately. brain damage, liver damage, potential frostbite”
Source discussion ↗
Top discussions (2)

Other options for anxiety

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate