PlainPill

Myo-Inositol

People mainly take Myo-Inositol for sleep, anxiety. Based on 16 first-hand reports and 102 meta-analyses & systematic reviews in the medical literature. Ranked #379 of 1,974 overall.

31
User score
Mostly positive
38% positive0% mixed19% negative44% unclear

Of reports that state an outcome, 67% are positive.

Clinical research
AStrong research base
102
meta-analyses
143
RCTs
8,361
papers

What Myo-Inositol does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

J Clin Endocrinol Metab · 2024 · Meta-analysis / systematic review
Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines

Conclusion: The evidence supporting the use of inositol in the management of PCOS is limited and inconclusive. Clinicians and their patients should consider the uncertainty of the evidence together with individual values and preferences when engaging in shared decision-making regarding the use of inositol for PCOS.

PubMed 38163998 ↗
Front Endocrinol (Lausanne) · 2024 · Meta-analysis / systematic review
Effects of different supplements on Hashimoto's thyroiditis: a systematic review and network meta-analysis

Conclusion: During a 6-month treatment, the use of Myo-inositol, Vitamin D alone, and the combination of selenium, and Myo-inositol did not effectively reduce TPOAb (Myo-inositol: SMD:-1.94, 95% CI: -6.75, 2.87; Vitamin D: SMD: -2.54, 95% CI: -6.51,1.42; Se+Myo-inositol: SMD: -3.01, 95% CI: -8.96,2.93) or TgAb (Myo-inositol: SMD:-2.02, 95% CI: -6.52, 2.48; Vitamin D: SMD: -2.73, 95% CI: -6.44,0.98; Se+Myo-inositol: SMD: -3.64, 95% CI: -9.20,1.92) levels. Therefore, we recommend that patients with HT(Hashimoto's Thyroiditis) be given an appropriate amount of selenium as an auxiliary treatment during standa

PubMed 39698034 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

12 gdaily for 4 weeks
high dosesas reported
10-11 gas reported
900 mgdaily
900 mgas reported
monthlyas reported

Reported side effects

How often each side effect came up across all reports.

muscle spasms ×1hypersalivation ×1facial pressure ×1twitches ×1sedation ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

“I took Myo inositol 12g a day for 4 weeks over a year ago and it has severely damaged my cognition and caused constant facial pressure”
Source discussion ↗
“Myo-Inositol at high doses made a very obvious difference for me.”
Source discussion ↗
“Have you tried myo inisitol? Some 3 AM wake ups are a because their liver is running low on glycogen.”
Source discussion ↗
“Myo-Inositol before bed is also fantastic! I take 10 - 11 grams 2 hours before bed”
Source discussion ↗
“This mood stabilizer was too sedating for me, I think because of the GABA. I didn't miss it when I switched to just L-theanine.”
Source discussion ↗
Top discussions (5)

Other options for sleep

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate