Methylated Folate
People mainly take Methylated Folate for mood, energy, anxiety. Based on 5 first-hand reports and 0 meta-analyses & systematic reviews in the medical literature. Ranked #830 of 1,974 overall.
Of reports that state an outcome, 67% are positive.
What Methylated Folate does, according to users
Of the people who reported each effect, the share who said it got better.
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
No randomized controlled trials in humans found on PubMed. The grade measures how much human research exists — read the conclusions below for what it found.
Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“General health: collogen, multivitamin pack, fishoil, methylated folate and B12”
“Methylated Folate should fix the root cause of my Depression and Anxiety.”
“B6 P5P, methylated folate, L-tyrosine/NALT...all boost dopamine.”
“I learned that I was VERY deficient in vitamin B9. So was my daughter. We both started mega-dosing metholated folate (B9) and felt better immediately.”
“methylated b supplement with extremely high doses of methylb12 and methylfolate...anxiety for months”
Top discussions (5)
- Been taking these for a month with no noticeable effect ↗
- What drugs and supplements do you take and why ? ↗
- Please don't take Methylated vitamins without testing or consulting your doctor. ↗
- What are some of the best supplements/ways to increase dopamine? ↗
- I feel awful and fatigued until I take a B Complex. What gives? ↗
Other options for mood
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate