People mainly take Honokiol for anxiety. Based on 4 first-hand reports and 5 meta-analyses & systematic reviews in the medical literature. Ranked #1526 of 1,974 overall.
Of reports that state an outcome, 0% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
At least one meta-analysis, or 5+ randomized controlled trials. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: The fact that SIRTs and their activators play a hundred different roles in IVDD helps to better understand their potential to develop further treatments for IVDD.
PubMed 38553713 ↗Conclusion: Although M. officinalis has rich pharmacological effects, the GI tract makes great contributions to it. The GI tract is not only an important place for absorption and metabolism but also a key site to help M. officinalis exert local and distal efficacy. Pharmacodynamical studies on the efficacies of distal tissues based on the contributions of the GI tract hold great potential for understanding the benefits of M. officinalis and providing new ideas for the treatment of important diseases.
PubMed 34400262 ↗Conclusion: We furthermore discuss the implications for selected phytochemicals to interfere in thrombosis and hemostasis, indicating their possible clinical relevance. Lastly, we provide guidance on which compounds are of interest for further platelet-related research.
PubMed 34715717 ↗Conclusion: Furthermore, neolignans played a role in protecting nerve cells via regulation of neuronal function, suppression of neurotoxicity, etc. This review summarizes the neuroprotective effect, primary mechanisms of the leading neolignans and provides new prospects for the treatment of brain disorders in the future.
PubMed 35784755 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“American Skullcap (high dose oral) + Honokiol extract from Magnolia Bark - benzoesque”
“Since studies have shown that these compounds are able to produce benzodiazepine-like effects with fewer side-effects then you can expect anxiolysis, muscle relaxant and anticonvulsant effects.”
“Honokiol/magnolia bark extract works decent”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate