Int J Dermatol · 2025
Glutathione as a skin-lightening agent and in melasma: a systematic reviewConclusion: IV glutathione is contraindicated due to lack of efficacy and side effects. It may work more as an antioxidant in melasma.
Possibly — but there are few reports. 90% of 10 people who reported on Glutathione for skin & hair say it improved. 10% noticed no change and 0% say it got worse.
“IM 600mg 2x week. My head is clear, my energy is so much better and my skin is glowing!”
Conclusion: IV glutathione is contraindicated due to lack of efficacy and side effects. It may work more as an antioxidant in melasma.
Conclusion: Current evidence of the skin whitening effect of glutathione is still inconclusive due to the quality of included studies and inconsistent findings. However, there is a trend that glutathione might brighten skin color at skin-exposed area.
Based on few reports — treat as anecdotal. Information only — not medical advice. How we count