People mainly take Cissus for pain & inflammation. Based on 13 first-hand reports and 6 meta-analyses & systematic reviews in the medical literature. Ranked #674 of 3,539 overall.
Of reports that state an outcome, 100% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: However, high-quality studies remain needed. Copyright © 2017 John Wiley & Sons, Ltd.
PubMed 28165166 ↗Conclusion: The CQ intervention was significantly associated with increased serum parathyroid hormone levels, with no significant effects on other bone-related biomarkers. Although there were a limited number of studies, these findings suggest its potential for modulating bone health; however, further research is needed to confirm these results and explore its clinical applications.
PubMed 40707943 ↗Conclusion: In conclusion, compounds containing ephedra, CQ, ginseng, bitter melon, and zingiber were found to be effective in the management of obesity. Attention to these natural compounds would open a new approach for novel therapeutic and more effective agents.
PubMed 19575486 ↗Conclusion: There is currently insufficient evidence to recommend any of the herbal medicines for weight loss included in the present review.
PubMed 31984610 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
First-hand experiences, quoted verbatim. We show one positive and one negative where both exist.
“This works more for bone regeneration but also reduces joint inflammation and seems to be helping me.”
“I took USPLabs Cissus and within about 3-4 weeks I had no more pain in my elbow.”
“I'd strongly recommend MSM or Cissus. It is for protecting your joints!”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 3, 2026. How we rate