Based on 7 first-hand reports and 65 meta-analyses & systematic reviews in the medical literature. Ranked #1016 of 1,974 overall.
Of reports that state an outcome, 100% are positive.
Of the people who reported each effect, the share who said it got better.
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Several plasma and serum metabolites, including amino acids, lipids, and carbohydrates, are associated with type 2 diabetes risk.
PubMed 35349649 ↗Conclusion: A large-scale analysis comprising ∼831 000 subjects revealed novel genetic determinants of MI and implicated SLC44A3 in the pathophysiology of vulnerable plaques.
PubMed 33532862 ↗Conclusion: Current evidence suggests that patients are unlikely to develop complications if the plasma total homocysteine concentration is maintained below 120 μmol/L. Nevertheless, we recommend keeping the concentration below 100 μmol/L because levels fluctuate and the complications associated with high levels are so serious.
PubMed 27778219 ↗Conclusion: The exceptions were β-hydroxy β-methylbutyrate and betaine, which can be considered effective for male athletes. Eurycoma longifolia, a blend of Punica granatum fruit rind and Theobroma cacao seed extracts (Tesnor™) and purified Shilajit extract (PrimaVie™) can be considered possibly effective for men with late-onset hypogonadism; Eurycoma longifolia and Withania somnifera possibly effective for healthy men; and a non-hormonal aromatase inhibitor (Novadex XT™) possibly effective for male athletes.
PubMed 37697053 ↗As stated by users — not a recommendation. Follow the label or your doctor.
How often each side effect came up across all reports.
Verbatim quotes, shortened only — each links to the original discussion.
“The core ingredients in my pre are: Creatine Citrulline Beta-alanine Betaine DMAA Huperzine”
“The holy trinity that I think everyone should take is taurine, creatine, and betaine.”
“Nutrients that help recycle Methionine from Homocysteine (Betaine/TMG, B9, B12) both increase Methionine and decrease Homocysteine, so they do not carry the heart/brain damage risk”
“Betaine – 2500mg”
“I take a 10x lions mane, 5,000iu vitamin D with k2, occasionally supplement magnesium, 2 fish oil capsules, creatine and betaine”
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate