Antidepressants
People mainly take Antidepressants for mood, energy. Based on 13 first-hand reports. Ranked #941 of 1,974 overall.
15
User score
Mostly negative8% positive23% mixed46% negative23% unclear
Of reports that state an outcome, 10% are positive.
Clinical research
Research pending
What Antidepressants does, according to users
Of the people who reported each effect, the share who said it got better.
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
Research data for Antidepressants is being compiled.
Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
6 monthsas reported
Reported side effects
How often each side effect came up across all reports.
manic episodes ×1emotional numbing ×1colitis ×1
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“I was on an anti-depressant for 6 months but it caused manic episodes”
“I think conventional antidepressants also do but obviously can come with some undesirable side effects.”
“I am on all kinds of anti depressants, doing ect, supplements(magesium, fish oil, etc)”
“The effect of ADs is small overall and lifestyle changes have a bigger effect.”
“has done what antidepressant meds could not”
Top discussions (5)
- Genuine biohack for anxiety and depression ↗
- Best supplements for depression ? ↗
- Mental health is horrible ↗
- Low dose of caffeine enhances the efficacy of antidepressants in major depressive disorder and the underlying neural substrates - PubMed [2017] ↗
- NAC is incredible for me and it's a crime that doctors don't prescribe it. ↗
Other options for mood
Resistance Training
Lifestyle · 53 reports
100% report better mood
Mostly positive
Retatrutide
Peptide · 298 reports
69% report better mood
Mostly positiveBResearch: Moderate
Caffeine + L-Theanine
Supplement · 46 reports
100% report better mood
Mostly positive
Tirzepatide
Medication · 219 reports
76% report better mood
Mostly positiveAResearch: Strong
Creatine Monohydrate
Supplement · 139 reports
88% report better mood
Mostly positiveAResearch: Strong
Magnesium Malate
Supplement · 103 reports
100% report better mood
Mostly positiveDResearch: None
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate