Conclusion: In this review, we summarize existing metabolomic studies related to glaucoma biomarker identification and point out a series of metabolic disorders in OAG patients, providing information on the molecular mechanism changes in glaucoma. Additional studies are needed to validate existing findings, and future research will need to explore the potential overlap between different biological fluids.
PubMed 33956051 ↗Spermidine
People mainly take Spermidine for skin & hair, focus. Based on 25 first-hand reports and 9 meta-analyses & systematic reviews in the medical literature. Ranked #691 of 1,974 overall.
Of reports that state an outcome, 67% are positive.
What Spermidine does, according to users
Of the people who reported each effect, the share who said it got better.
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Conclusion: Levels of food-derived monoamine oxidase inhibitors and anti-bacterial compounds, the potential modulators of ADAS-bacteria growth and biogenic amine production, were altered in C&A versus NNI. ADAS is attributable to potentially modifiable risk factors of AD associated diseases.
PubMed 31561379 ↗Conclusion: The results imply a positive outlook for the reviewed substances to qualify as a novel treatment option for AD. A combination of nutraceutical substances and other preventive measures could have significant clinical impact in a multi-layered therapy approach to counter AD.
PubMed 33353228 ↗Conclusion: Bioinformatic investigation of these genes revealed a synchronous network of transcriptional regulation in the polyamine and purine biosynthesis pathways. Beyond the specific implications for prostate cancer, this work establishes a much-needed model for the evaluation, cross-validation, and comparison of multiple cancer profiling studies.
PubMed 12154050 ↗Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
Reported side effects
How often each side effect came up across all reports.
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“Sperimidine.”
“Studies suggest spermidine can improve memory and slow cognitive decline.”
“if you look at the study they use 1.2mg spermidine, not 1.2g”
“Each has made a noticible improment in mental clarity and mood (mild)”
“I took it for years and didn’t notice too much of a difference”
Top discussions (5)
- Focusing on mitochondria health has been an absolute game changer ↗
- 40M. I biohacked my way from severe alcoholism, ed/pied, severe anxiety to washington monument sized boners every morning, and almost no anxiety. In less than 1.5 years. AMA. ↗
- A study tracked 146 nutrients in 829 people across 15 years to see their effects on mortality and longevity. Guess which nutrient out of those 146 was easily ranked as the most beneficial? ↗
- Anything new? ↗
- Spermidine results (2024): "We report that higher spermidine blood levels are associated not only with deteriorated brain health but also with less advantageous markers of sleep quality in older adults." ↗
Other options for skin & hair
User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate