PlainPill

Spermidine

People mainly take Spermidine for skin & hair, focus. Based on 25 first-hand reports and 9 meta-analyses & systematic reviews in the medical literature. Ranked #691 of 1,974 overall.

23
User score
Mostly positive
16% positive4% mixed4% negative76% unclear

Of reports that state an outcome, 67% are positive.

Clinical research
AStrong research base
9
meta-analyses
41
RCTs
10,937
papers

What Spermidine does, according to users

Of the people who reported each effect, the share who said it got better.

What the research says

Systematic reviews and meta-analyses from PubMed, with their published conclusions.

AStrong research base

3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.

Invest Ophthalmol Vis Sci · 2021 · Meta-analysis / systematic review
Metabolomics in Glaucoma: A Systematic Review

Conclusion: In this review, we summarize existing metabolomic studies related to glaucoma biomarker identification and point out a series of metabolic disorders in OAG patients, providing information on the molecular mechanism changes in glaucoma. Additional studies are needed to validate existing findings, and future research will need to explore the potential overlap between different biological fluids.

PubMed 33956051 ↗
J Alzheimers Dis · 2019 · Meta-analysis / systematic review
Discovery of Gut Bacteria Specific to Alzheimer's Associated Diseases is a Clue to Understanding Disease Etiology: Meta-Analysis of Population-Based Data on Human Gut Metagenomics and Metabolomics

Conclusion: Levels of food-derived monoamine oxidase inhibitors and anti-bacterial compounds, the potential modulators of ADAS-bacteria growth and biogenic amine production, were altered in C&A versus NNI. ADAS is attributable to potentially modifiable risk factors of AD associated diseases.

PubMed 31561379 ↗
Cancer Res · 2002 · Meta-analysis / systematic review
Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer

Conclusion: Bioinformatic investigation of these genes revealed a synchronous network of transcriptional regulation in the polyamine and purine biosynthesis pathways. Beyond the specific implications for prostate cancer, this work establishes a much-needed model for the evaluation, cross-validation, and comparison of multiple cancer profiling studies.

PubMed 12154050 ↗

Dosage people report

As stated by users — not a recommendation. Follow the label or your doctor.

1 gas reported
10 mgdaily
dailyas reported
10mgdaily
8 mgdaily
1.2 mgdaily

Reported side effects

How often each side effect came up across all reports.

body heat ×1insomnia ×1

What users say

Verbatim quotes, shortened only — each links to the original discussion.

Other options for skin & hair

User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate