J Am Acad Dermatol · 2024 · Meta-analysis / systematic review
Guidelines of care for the management of acne vulgarisConclusion: These guidelines provide evidence-based recommendations for the management of acne vulgaris.
PubMed 38300170 ↗Doxycycline
People mainly take Doxycycline for skin & hair, digestion. Based on 6 first-hand reports and 314 meta-analyses & systematic reviews in the medical literature. Ranked #1097 of 1,974 overall.
14
User score
Mixed17% positive17% mixed33% negative33% unclear
Of reports that state an outcome, 25% are positive.
Clinical research
AStrong research base
314
meta-analyses
841
RCTs
20,608
papers
What Doxycycline does, according to users
Of the people who reported each effect, the share who said it got better.
betterno changeworse
What the research says
Systematic reviews and meta-analyses from PubMed, with their published conclusions.
AStrong research base
3+ meta-analyses or systematic reviews and 10+ randomized controlled trials in humans. The grade measures how much human research exists — read the conclusions below for what it found.
Syst Rev · 2024 · Meta-analysis / systematic review
Efficacy and safety of antibiotics for treatment of leptospirosis: a systematic review and network meta-analysisConclusion: Findings recommend that leptospirosis patients be treated with antibiotics, which significantly reduced the leptospirosis defervescence time. Cephalosporins, doxycycline, and penicillin are suggested, and azithromycin may be a suitable alternative for drug-resistant cases.
PubMed 38627798 ↗J Eur Acad Dermatol Venereol · 2025 · Meta-analysis / systematic review
Acne and the cutaneous microbiome: A systematic review of mechanisms and implications for treatmentsConclusion: Despite the heterogeneity of study types and microbiome classifications limiting the analysis, this review underscores the complexity of microbial involvement in acne pathogenesis. It delineates the effects of acne therapeutics on microbial diversity, abundance, and composition, emphasizing the necessity for personalized approaches in acne management based on microbiome modulation.
PubMed 39269130 ↗Sex Transm Dis · 2025 · Meta-analysis / systematic review
Efficacy of Doxycycline as Preexposure and/or Postexposure Prophylaxis to Prevent Sexually Transmitted Diseases: A Systematic Review and Meta-AnalysisConclusion: The use of doxy-PEP might reduce the first STI, mainly C. trachomatis , if used within 72 hours after condomless sex. The use of doxy-PREP might also decrease the chance of any STI; however, only 1 study was evaluated.
PubMed 39316078 ↗Clin Infect Dis · 2023 · Meta-analysis / systematic review
Efficacy of Doxycycline for Mild-to-Moderate Community-Acquired Pneumonia in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsPubMed 35903011 ↗Dosage people report
As stated by users — not a recommendation. Follow the label or your doctor.
multiple-month courseas reported
Reported side effects
How often each side effect came up across all reports.
stomach issues ×1liver damage ×1
What users say
Verbatim quotes, shortened only — each links to the original discussion.
“Doxycycline for possible Lyme”
“I did a cycle of doxycycline (for lime), but everything came back clear, and the doxycycline had no effect.”
“I would definitely not have gone on a multiple-month Doxycycline course which absolutely wrecked my digestion and 2 years later it's only gotten worse”
“I don’t think I need doxycycline anymore”
“What helped was getting prescribed on tretinoin and doxycycline which is like a anti bacterial acne drug”
Top discussions (5)
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User data from public discussions; research from PubMed. Information only, not medical advice — talk to a doctor before starting, stopping or combining anything. Data updated October 2, 2026. How we rate