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Caffeine, nicotine, alcohol and other everyday psychoactive substances. 144 rated.
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A–Z
Goal
Any
Weight loss
Appetite
Focus
Energy
Sleep
Anxiety
Mood
Memory
Performance
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Pain & inflammation
Digestion
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Hormones
Heart & lipids
Skin & hair
Longevity
Research
Any
Moderate or strong
Strong only
4 results
1
60
Yerba Mate
Substance
Energy
Focus
Mood
100%
report better
Digestion
2 reports
Mostly positive
A
Research: Strong
2
54
Coffee
Substance
Energy
Focus
Anxiety
33%
report better
Digestion
6 reports
Mixed
Research pending
3
52
Caffeine
Substance
Energy
Focus
Anxiety
33%
report better
Digestion
3 reports
Mixed
A
Research: Strong
4
50
Kratom
Substance
Mood
Anxiety
Energy
25%
report better
Digestion
4 reports
Mixed
B
Research: Moderate
Best substances — ranked by user results & research — PlainPill